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Cardiac regeneration following myocardial infarction: the need for regeneration and a review of cardiac stromal cell populations used for transplantation

Abstract:

Myocardial infarction is a leading cause of death globally due to the inability of the adult human heart to regenerate after injury. Cell therapy using cardiac-derived progenitor populations emerged about two decades ago with the aim of replacing cells lost after ischaemic injury. Despite early promise from rodent studies, administration of these populations has not translated to the clinic. We will discuss the need for cardiac regeneration and review the debate surrounding how cardiac progen...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1042/bst20210231

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Oxford college:
St Catherine's College
Role:
Author
ORCID:
0000-0003-1118-5015
Publisher:
Portland Press Publisher's website
Journal:
Biochemical Society Transactions Journal website
Volume:
50
Issue:
1
Pages:
269–281
Publication date:
2022-02-07
Acceptance date:
2022-01-06
DOI:
EISSN:
1470-8752
ISSN:
0300-5127
Pmid:
35129611
Language:
English
Keywords:
Pubs id:
1238715
Local pid:
pubs:1238715
Deposit date:
2022-02-16

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