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The molecular basis for an allosteric inhibition of K+-flux gating in K2P channels

Abstract:

Two-pore-domain potassium (K2P) channels are key regulators of many physiological and pathophysiological processes and thus emerged as promising drug targets. As for other potassium channels, there is a lack of selective blockers, since drugs preferentially bind to a conserved binding site located in the central cavity. Thus, there is a high medical need to identify novel drug-binding sites outside the conserved lipophilic central cavity and to identify new allosteric mechanisms...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.7554/eLife.39476

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Role:
Author
ORCID:
0000-0003-2850-2523
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Role:
Author
ORCID:
0000-0002-6192-5651
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Publisher:
eLife Sciences Publications Publisher's website
Journal:
eLife Journal website
Volume:
8
Article number:
e39476
Publication date:
2019-02-26
Acceptance date:
2019-02-06
DOI:
EISSN:
2050-084X
Pmid:
30803485
Source identifiers:
980475
Language:
English
Keywords:
Pubs id:
pubs:980475
UUID:
uuid:811cff9b-877d-4e4d-8689-c8915a0cf2f0
Local pid:
pubs:980475
Deposit date:
2019-09-20

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