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Thesis

The impact of genetic drift on the distribution and uses of linkage disequilibrium

Abstract:

With the advent of Genome Wide Association Studies (GWAS), researchers have gained unprecedented access to data in order to examine associations between variants and complex traits and diseases. To analyze these studies, researchers have typically utilized measurements of Linkage Disequilibrium (LD) from the GWAS population or from a reference population which may be genetically drifted relative to the GWAS. However, these measurements are only point estimates and thus, do not capture the ...

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Division:
MSD
Department:
NDM
Role:
Author

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Role:
Supervisor
Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
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Subjects:
Deposit date:
2022-04-24

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