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Structure of human complement C8, a precursor to membrane attack

Abstract:

Complement component C8 plays a pivotal role in the formation of the membrane attack complex (MAC), an important antibacterial immune effector. C8 initiates membrane penetration and coordinates MAC pore formation. High-resolution structures of C8 subunits have provided some insight into the function of the C8 heterotrimer; however, there is no structural information describing how the intersubunit organization facilitates MAC assembly. We have determined the structure of C8 by electron micros...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.jmb.2010.10.031

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Research group:
Division of Structural Biology
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
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Institution:
Cardiff University
Department:
Department of Medical Biochemistry and Immunology,School of Medicine
Role:
Author
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Institution:
Cardiff University
Department:
Department of Medical Biochemistry and Immunology,School of Medicine
Role:
Author
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Institution:
Spanish National Research Council, Madrid, Spain
Role:
Author
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Funding agency for:
Bubeck, D
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Funding agency for:
Bubeck, D
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Funding agency for:
Morgan, B
Grant:
068590
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Publisher:
Elsevier Publisher's website
Journal:
Journal of Molecular Biology Journal website
Volume:
405
Issue:
2
Pages:
325-330
Publication date:
2011-01-01
DOI:
ISSN:
00222836
Language:
English
Keywords:
Subjects:
UUID:
uuid:815c564d-c56e-43d0-b458-1f8c87da8983
Local pid:
ora:5588
Deposit date:
2011-07-19

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