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13C pyruvate transport across the blood-brain barrier in preclinical hyperpolarised MRI

Abstract:

Hyperpolarised MRI with Dynamic Nuclear Polarisation overcomes the fundamental thermodynamic limitations of conventional magnetic resonance, and is translating to human studies with several early-phase clinical trials in progress including early reports that demonstrate the utility of the technique to observe lactate production in human brain cancer patients. Owing to the fundamental coupling of metabolism and tissue function, metabolic neuroimaging with hyperpolarised [1-13C]pyruvate has the...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41598-018-33363-5

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
ORCID:
0000-0002-6258-1299
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
Role:
Author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Role:
Author
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Aarhus University More from this funder
National Institute for Health Research More from this funder
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Publisher:
Nature Research Publisher's website
Journal:
Scientific Reports Journal website
Volume:
8
Article number:
15082
Publication date:
2018-10-10
Acceptance date:
2018-09-26
DOI:
ISSN:
2045-2322
Source identifiers:
923354
Pubs id:
pubs:923354
UUID:
uuid:81b30e3b-14b1-48b4-bb86-46e22faeff53
Local pid:
pubs:923354
Deposit date:
2018-10-03

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