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Journal article

Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease

Abstract:

We report results of a nonsynonymous SNP scan for ulcerative colitis and identify a previously unknown susceptibility locus at ECM1. We also show that several risk loci are common to ulcerative colitis and Crohn's disease (IL23R, IL12B, HLA, NKX2-3 and MST1), whereas autophagy genes ATG16L1 and IRGM, along with NOD2 (also known as CARD15), are specific for Crohn's disease. These data provide the first detailed illustration of the genetic relationship between these common inflammatory bowel diseases.

Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/ng.145

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Wellcome Trust More from this funder
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Publisher:
Springer Nature Publisher's website
Journal:
Nature Genetics Journal website
Volume:
40
Issue:
6
Pages:
710-712
Publication date:
2008-04-27
Acceptance date:
2008-03-14
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
Pmid:
18438406
Source identifiers:
135766
Language:
English
Keywords:
Pubs id:
pubs:135766
UUID:
uuid:82031572-fcec-4d22-a86a-783738a7ddc4
Local pid:
pubs:135766
Deposit date:
2018-08-09

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