Thesis icon

Thesis

Towards a universally effective HLA-E-targeted HIV vaccine - a structural and biophysical exploration

Abstract:

Through major histocompatibility complex class I leader sequence-derived peptide (VL9) binding and CD94/NKG2 receptor engagement, human leucocyte antigen E (HLA-E) reports cellular health to NK cells. Previous studies demonstrated a strong bias for VL9 binding by HLA-E, a preference subsequently supported by structural analyses. However, Mycobacteria tuberculosis (Mtb) infection and Rhesus cytomegalovirus-vectored SIV vaccination revealed contexts where HLA-E and its rhesus orthologue, Mamu-E...

Expand abstract

Actions


Authors


More by this author
Division:
MSD
Department:
NDM
Oxford college:
Linacre College
Role:
Author

Contributors

Role:
Supervisor
Role:
Supervisor
Bill and Melinda Gates Foundation More from this funder
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
Deposit date:
2020-10-04

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP