Thesis
Metabolic control of energetics in human heart and skeletal muscle
- Abstract:
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Myocardial and skeletal muscle high energy phosphate metabolism is abnormal in heart failure, but the pathophysiology is not understood. Plasma non-esterified fatty acids (NEFA) increase in heart failure due to increased sympathetic drive, and regulate the transcription of mitochondrial uncoupling protein-3 (UCP3), through peroxisome proliferator-activated receptor-α. The aim of the work in this thesis was to determine whether cardiac PCr/ATP ratios and skeletal muscle PCr kinetics during e...
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Authors
Contributors
+ Clarke, K
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Supervisor
+ Evans, R
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Supervisor
Funding
+ British Heart Foundation
More from this funder
Funding agency for:
Johnson, AW
Grant:
FS/07/061/23715
Bibliographic Details
- Publication date:
- 2012
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:82c0dce6-a162-4c08-b061-3ea7f2e35134
- Local pid:
- ora:6323
- Deposit date:
- 2012-07-04
Terms of use
- Copyright holder:
- Andrew Johnson
- Copyright date:
- 2012
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