Early antigen presentation of protective HIV-1 KF11Gag and KK10Gag epitopes from incoming viral particles facilitates rapid recognition of infected cells by specific CD8+ T cells.

Journal article

CD8(+) T cells are major players in antiviral immunity against human immunodeficiency virus type 1 (HIV-1) through recognition of viral epitopes presented on the surface of infected cells. However, the early events involving HIV-1 epitope presentation to CD8(+) T cells remain poorly understood but are nonetheless crucial for the rapid clearance of virus-infected cells. Here, we comprehensively studied the kinetics of antigen presentation of two protective epitopes, KF11Gag and KK10Gag, restri...

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Authors: Kløverpris, H; Payne, R; Sacha, J; Rasaiyaah, J; Chen, F

• Publication status: Published
• Journal: Journal of virology
• Volume: 87
• Issue: 5
• Pages: 2628-2638
• Publication date: 2013-03-01
• DOI: 10.1128/jvi.02131-12
• EISSN: 1098-5514
• ISSN: 0022-538X
• Language: English
• Keywords: Cell Line; Epitopes; gag Gene Products, Human Immunodeficiency Virus; Antigen Presentation; Virus Replication; HIV-1; Lymphocyte Activation; HIV Infections; CD8-Positive T-Lymphocytes; Humans; Epitopes, T-Lymphocyte