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Transcriptomics of cortical gray matter thickness decline during normal aging

Abstract:

Introduction: We performed a whole-transcriptome correlation analysis, followed by the pathway enrichment and testing of innate immune response pathway analyses to evaluate the hypothesis that transcriptional activity can predict cortical gray matter thickness (GMT) variability during normal cerebral aging.

Methods: Transcriptome and GMT data were available for 379 individuals (age range = 28–85) community-dwelling members of large extended Mexican American familie...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
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Publisher:
Elsevier Publisher's website
Journal:
NeuroImage Journal website
Volume:
82
Pages:
273-283
Publication date:
2013-11-15
DOI:
ISSN:
1053-8119
Source identifiers:
446007
Language:
English
Keywords:
Subjects:
Pubs id:
pubs:446007
UUID:
uuid:831e2349-46e1-48e5-b89b-22060fed67d8
Local pid:
pubs:446007
Deposit date:
2014-01-18

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