Journal article icon

Journal article

Endogenous hepcidin and its agonist mediate resistance to selected infections by clearing non-transferrin-bound iron

Abstract:

The iron-regulatory hormone hepcidin is induced early in infection, causing iron sequestration in macrophages and decreased plasma iron; this is proposed to limit the replication of extracellular microbes, but could also promote infection with macrophage-tropic pathogens. The mechanisms by which hepcidin and hypoferremia modulate host defense, and the spectrum of microbes affected, are poorly understood. Using mouse models, we show that hepcidin was selectively protective against siderophilic...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM - Investigative Medicine Division
Role:
Author
Publisher:
American Society of Hematology Publisher's website
Journal:
Blood Journal website
Volume:
130
Issue:
3
Pages:
245-257
Publication date:
2017-07-20
Acceptance date:
2017-04-29
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
Pmid:
28465342
Source identifiers:
693467

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP