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Tracking Dengue virus intra-host genetic diversity during human-to-mosquito transmission.

Abstract:

Dengue virus (DENV) infection of an individual human or mosquito host produces a dynamic population of closely-related sequences. This intra-host genetic diversity is thought to offer an advantage for arboviruses to adapt as they cycle between two very different host species, but it remains poorly characterized. To track changes in viral intra-host genetic diversity during horizontal transmission, we infected Aedes aegypti mosquitoes by allowing them to feed on DENV2-infected pati...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.1371/journal.pntd.0004052

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Role:
Editor
Publisher:
PLoS Publisher's website
Journal:
PLoS neglected tropical diseases Journal website
Volume:
9
Issue:
9
Pages:
e0004052
Publication date:
2015-09-01
Acceptance date:
2015-08-12
DOI:
ISSN:
1935-2727 and 1935-2735
Pmid:
26325059

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