The hippocampus in schizophrenia: a review of the neuropathological evidence and its pathophysiological implications.

Journal article

This paper puts the case for the hippocampus as being central to the neuropathology and pathophysiology of schizophrenia. The evidence comes from a range of approaches, both in vivo (neuropsychology, structural and functional imaging) and post mortem (histology, morphometry, gene expression, and neurochemistry). Neuropathologically, the main positive findings concern neuronal morphology, organisation, and presynaptic and dendritic parameters. The results are together suggestive of an altered ...

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Authors: Harrison, P

• Publication status: Published
• Journal: Psychopharmacology
• Volume: 174
• Issue: 1
• Pages: 151-162
• Publication date: 2004-06-01
• DOI: 10.1007/s00213-003-1761-y
• EISSN: 1432-2072
• ISSN: 0033-3158
• Language: English
• Keywords: Glutamic Acid; Hippocampus; Schizophrenia; Neurons; Humans; Functional Laterality; Synapses; Animals