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Thesis

Targeting PDK and PARP to improve radiation response in preclinical models of non-small cell lung cancer

Abstract:

Approximately 50 % of all NSCLC patients receive radiation therapy during the course of their disease, and the quest to enhance the radiation response of these patients is still ongoing. Here, we investigate the potential to increase the radiation response of NSCLC by targeting the PI3K signalling pathway with PDK1 inhibitors and/or targeting DNA repair with the PARP inhibitor olaparib. The in vitro radiosensitising effect of the PARP inhibitor olaparib and the PDK1 inhibitors BX9...

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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Sub department:
CRUK/MRC Ox Inst for Radiation Oncology
Oxford college:
St Edmund Hall
Role:
Author

Contributors

Division:
MSD
Department:
Oncology
Sub department:
CRUK/MRC Ox Inst for Radiation Oncology
Role:
Supervisor
Publication date:
2013
Type of award:
MSc by Research
Level of award:
Masters
Awarding institution:
Oxford University, UK
Language:
English
Keywords:
Subjects:
UUID:
uuid:840f99ef-c1ce-48b1-bc95-d40860bf2e27
Local pid:
ora:10455
Deposit date:
2015-03-05

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