Thesis
Improving intraperitoneal adenovirus virotherapy for ovarian cancer
- Abstract:
-
The use of intraperitoneal (i.p.) adenovirus virotherapy of ovarian cancer is currently limited by insufficient efficacy and high toxicity. Both factors are associated with adenovirus serotype 5 (Ad5) in this setting and may be serotype-specific. Low levels of uptake receptors (CAR and αV integrins) on ovarian tumour cells and widespread immunity against Ad5 among patients appear to restrict efficacy and intraperitoneal inflammatory responses against Ad5 were among the reasons for the te...
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Authors
Contributors
+ Morrison, J
Division:
MSD
Department:
Pharmacology
Role:
Supervisor
+ Seymour, L
Division:
MSD
Department:
Pharmacology
Role:
Supervisor
Bibliographic Details
- Publication date:
- 2011
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:841e4334-f408-4da3-b8e6-1d29350c5304
- Local pid:
- ora:6280
- Deposit date:
- 2012-06-07
Terms of use
- Copyright holder:
- Thoma, CMM
- Copyright date:
- 2011
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