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Journal article

Importance of intracellular pH in determining the uptake and efficacy of the weakly basic chemotherapeutic drug, doxorubicin.

Abstract:

Low extracellular pH (pH(e)), that is characteristic of many tumours, tends to reduce the uptake of weakly basic drugs, such as doxorubicin, thereby conferring a degree of physiological resistance to chemotherapy. It has been assumed, from pH-partition theory, that the effect of intracellular pH (pH(i)) is symmetrically opposite, although this has not been tested experimentally. Doxorubicin uptake into colon HCT116 cells was measured using the drug's intrinsic fluorescence under conditions th...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pone.0035949

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
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Institution:
University of Oxford
Role:
Author
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Institution:
University of Oxford
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
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Funding agency for:
Swietach, P
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Funding agency for:
Swietach, P
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Funding agency for:
Vaughan-Jones, R
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Funding agency for:
Harris, A
Medical Research Council More from this funder
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Publisher:
Public Library of Science Publisher's website
Journal:
PloS one Journal website
Volume:
7
Issue:
4
Article number:
e35949
Publication date:
2012-01-01
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
Source identifiers:
329037
Language:
English
Keywords:
UUID:
uuid:845bc3b1-7427-42e7-b4b5-a35651d861bb
Local pid:
pubs:329037
Deposit date:
2012-12-19

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