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Fine-mapping identifies multiple prostate cancer risk loci at 5p15, one of which associates with TERT expression.

Abstract:

Associations between single nucleotide polymorphisms (SNPs) at 5p15 and multiple cancer types have been reported. We have previously shown evidence for a strong association between prostate cancer (PrCa) risk and rs2242652 at 5p15, intronic in the telomerase reverse transcriptase (TERT) gene that encodes TERT. To comprehensively evaluate the association between genetic variation across this region and PrCa, we performed a fine-mapping analysis by genotyping 134 SNPs using a custom Illumina iS...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/hmg/ddt086

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Grant:
HEALTH-F2-2009-223175
Institute of Cancer Research More from this funder
Orchid Cancer Appeal More from this funder
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Publisher:
Oxford University Press Publisher's website
Journal:
Human molecular genetics Journal website
Volume:
22
Issue:
12
Pages:
2520-2528
Publication date:
2013-06-01
DOI:
EISSN:
1460-2083
ISSN:
0964-6906
Source identifiers:
390878

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