Journal article
Cinacalcet rectifies hypercalcemia in a patient with familial hypocalciuric hypercalcemia type 2 (FHH2) caused by a germline loss‐of‐function Gα11 mutation
- Abstract:
-
G‐protein subunit α‐11 (Gα11) couples the calcium‐sensing receptor (CaSR) to phospholipase C (PLC)‐mediated intracellular calcium (Ca2+i) and mitogen‐activated protein kinase (MAPK) signaling, which in the parathyroid glands and kidneys regulates parathyroid hormone release and urinary calcium excretion, respectively. Heterozygous germline loss‐of‐function Gα11 mutations cause familial hypocalciuric hypercalcemia type 2 (FHH2), for which effective therapies are currently not available. Here, ...
Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
-
-
(Version of record, pdf, 1.1MB)
-
- Publisher copy:
- 10.1002/jbmr.3241
Why is the content I wish to access not available via ORA?
Bibliographic data (the information relating to research outputs) and full-text items (e.g. articles, theses, reports, etc.) arrive in ORA from several different sources. Unfortunately we are not able to make available the full-text for every research output.
Please contact the ORA team (
) if you have queries regarding unavailable content OR if you are aware of a full-text copy we can make available.
) if you have queries regarding unavailable content OR if you are aware of a full-text copy we can make available.
Content may be unavailable for the following four reasons
-
Version unsuitable
-
We have not obtained a suitable full-text for a given research output. See this page for more information.
-
Recently completed
-
Sometimes content is held in ORA but is unavailable for a fixed period of time to comply with the policies and wishes of rights holders.
-
Permissions
-
All content made available in ORA should comply with relevant rights, such as copyright. See this page for more information.
-
Clearance
-
Some thesis volumes scanned as part of the digitisation scheme funded by Dr Leonard Polonsky are currently unavailable due to sensitive material or uncleared third-party copyright content. We are attempting to contact authors whose theses are affected.
Alternative access to the full-text
You may be able to access the full-text directly from the publisher's website using the 'Publisher Copy' link in the 'Links & Downloads' box from a research output's ORA record page. This method may require an institutional or individual subscription to the journal/resource.
Authors
Funding
Finska Lakaresallskapet
More from this funder
Helsinki University Hospital Research Funds
More from this funder
National Institute for Health Research
More from this funder
Academy of Finland
More from this funder
Expand funders...
Bibliographic Details
- Publisher:
- Wiley Publisher's website
- Journal:
- Journal of Bone and Mineral Research Journal website
- Volume:
- 33
- Issue:
- 1
- Pages:
- 32-41
- Publication date:
- 2017-08-18
- Acceptance date:
- 2017-08-14
- DOI:
- EISSN:
-
1523-4681
- ISSN:
-
0884-0431
- Pmid:
-
28833550
- Source identifiers:
-
724219
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:724219
- UUID:
-
uuid:8480961f-d232-495f-8f68-0e4832db4a6d
- Local pid:
- pubs:724219
- Deposit date:
- 2017-09-01
Terms of use
- Copyright holder:
- Gorvin et al
- Copyright date:
- 2017
- Notes:
- © 2017 The Authors. Journal of Bone and Mineral Research Published by Wiley Periodicals Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
If you are the owner of this record, you can report an update to it here: Report update to this record