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Structure–activity relationship and crystallographic studies on 4-hydroxypyrimidine HIF prolyl hydroxylase domain inhibitors

Abstract:
The 2‐oxoglutarate‐dependent hypoxia inducible factor prolyl hydroxylases (PHDs) are targets for treatment of a variety of diseases including anaemia. One PHD inhibitor is approved for use for the treatment of renal anaemia and others are in late stage clinical trials. The number of reported templates for PHD inhibition is limited. We report structure–activity relationship and crystallographic studies on a promising class of 4‐hydroxypyrimidine‐containing PHD inhibitors.
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/cmdc.201900557

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Publisher:
Wiley Publisher's website
Journal:
ChemMedChem Journal website
Volume:
15
Issue:
3
Pages:
270-273
Publication date:
2019-12-03
Acceptance date:
2019-11-04
DOI:
EISSN:
1860-7187
ISSN:
1860-7179
Source identifiers:
1070090
Language:
English
Keywords:
Pubs id:
pubs:1070090
UUID:
uuid:84885a98-13b5-404a-a95a-f35821d2731e
Local pid:
pubs:1070090
Deposit date:
2019-11-05

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