Journal article
Structure–activity relationship and crystallographic studies on 4-hydroxypyrimidine HIF prolyl hydroxylase domain inhibitors
- Abstract:
- The 2‐oxoglutarate‐dependent hypoxia inducible factor prolyl hydroxylases (PHDs) are targets for treatment of a variety of diseases including anaemia. One PHD inhibitor is approved for use for the treatment of renal anaemia and others are in late stage clinical trials. The number of reported templates for PHD inhibition is limited. We report structure–activity relationship and crystallographic studies on a promising class of 4‐hydroxypyrimidine‐containing PHD inhibitors.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Accepted manuscript, 1.0MB)
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- Publisher copy:
- 10.1002/cmdc.201900557
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Authors
Funding
Bibliographic Details
- Publisher:
- Wiley Publisher's website
- Journal:
- ChemMedChem Journal website
- Volume:
- 15
- Issue:
- 3
- Pages:
- 270-273
- Publication date:
- 2019-12-03
- Acceptance date:
- 2019-11-04
- DOI:
- EISSN:
-
1860-7187
- ISSN:
-
1860-7179
- Source identifiers:
-
1070090
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:1070090
- UUID:
-
uuid:84885a98-13b5-404a-a95a-f35821d2731e
- Local pid:
- pubs:1070090
- Deposit date:
- 2019-11-05
Terms of use
- Copyright holder:
- Wiley‐VCH Verlag GmbH & Co. KGaA
- Copyright date:
- 2019
- Rights statement:
- © 2019 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim.
- Notes:
- This is the accepted manuscript version of the article. The final version is available online from Wiley at: https://doi.org/10.1002/cmdc.201900557
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