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Learning from the proteasome: how to fine-tune cancer immunotherapy

Abstract:

Cancer immunotherapy has recently emerged as a forefront strategy to fight cancer. Key players in antitumor responses are CD8+ cytolytic T lymphocytes (CTLs) that can detect tumor cells that carry antigens, in other words, small peptides bound to surface major histocompatibility complex (MHC) class I molecules. The success and safety of cancer immunotherapy strategies depends on the nature of the antigens recognized by the targeted T cells, their strict tumor specificity, and whether tumors a...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.trecan.2017.07.007

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Oxford Ludwig Institute
Role:
Author
Publisher:
Cell Press Publisher's website
Journal:
Trends in Cancer Journal website
Volume:
3
Issue:
10
Pages:
726-741
Publication date:
2017-08-24
Acceptance date:
2017-07-24
DOI:
EISSN:
2405-8025
ISSN:
2405-8033
Pmid:
28958390
Source identifiers:
734488
Language:
English
Keywords:
Pubs id:
pubs:734488
UUID:
uuid:84939cf6-9539-48e5-99b0-1595e8f40b2d
Local pid:
pubs:734488
Deposit date:
2017-11-09

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