Thesis
Human orthologues of Saccharomyces cerevisiae Trf4/5 non-canonical poly(A) polymerases
- Abstract:
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RNA waste in the budding yeast nucleus is degraded 3’-5’ via exosome-mediated pathways associated with the non-canonical poly(A) polymerases Trf4 and Trf5. Multiple sequence alignments identify POLS and PAPD5 as the human orthologues of Trf4 and Trf5. This research has investigated the degree of conservation and extent of divergence of POLS and PAPD5 from their orthologues. Mass spectrometric analysis identified interacting protein partners of POLS that are mostly nuclear and are associated w...
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Bibliographic Details
- Publication date:
- 2011
- Type of award:
- MSc by Research
- Level of award:
- Masters
- Awarding institution:
- Oxford University, UK
- URN:
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uuid:84adcce5-c6cc-4876-b4d4-0b1a94176001
- Local pid:
- ora:6679
Item Description
- Language:
- English
- Keywords:
- Subjects:
Terms of use
- Copyright holder:
- Kumudika Gibson
- Copyright date:
- 2011
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