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Human orthologues of Saccharomyces cerevisiae Trf4/5 non-canonical poly(A) polymerases

Abstract:

RNA waste in the budding yeast nucleus is degraded 3’-5’ via exosome-mediated pathways associated with the non-canonical poly(A) polymerases Trf4 and Trf5. Multiple sequence alignments identify POLS and PAPD5 as the human orthologues of Trf4 and Trf5. This research has investigated the degree of conservation and extent of divergence of POLS and PAPD5 from their orthologues. Mass spectrometric analysis identified interacting protein partners of POLS that are mostly nuclear and are associated w...

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Institution:
University of Oxford
Division:
MSD
Oxford college:
Queen's College
Role:
Author

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Division:
MSD
Department:
Pathology Dunn School
Role:
Supervisor
Publication date:
2011
Type of award:
MSc by Research
Level of award:
Masters
Awarding institution:
Oxford University, UK
Language:
English
Keywords:
Subjects:
UUID:
uuid:84adcce5-c6cc-4876-b4d4-0b1a94176001
Local pid:
ora:6679
Deposit date:
2013-01-29

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