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Journal article

Exploiting in silico modelling to enhance translation of liver cell therapies from bench to bedside

Abstract:

Cell therapies are emerging as promising treatments for a range of liver diseases but translational bottlenecks still remain including: securing and assessing the safe and effective delivery of cells to the disease site; ensuring successful cell engraftment and function; and preventing immunogenic responses. Here we highlight three therapies, each utilising a different cell type, at different stages in their clinical translation journey: transplantation of multipotent mesenchymal stromal/sign...

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Publication status:
Accepted
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MPLS
Department:
Mathematical Institute
Oxford college:
St Anne's College
Role:
Author
ORCID:
0000-0001-5285-0523
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Name:
Engineering and Physical Sciences Research Council
Grant:
EP/S003509/1
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Name:
Medical Research Council
Grant:
MR/T015489/1
Publisher:
Springer Nature
Journal:
npj Regenerative Medicine More from this journal
Acceptance date:
2024-03-07
EISSN:
2057-3995
Language:
English
Pubs id:
1782001
Local pid:
pubs:1782001
Deposit date:
2024-03-08

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