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Tackling statin intolerance with n-of-1 trials (TaSINI) in primary care: protocol for a feasibility randomised trial to increase statin adherence

Abstract:

INTRODUCTION: Statins reduce the incidence of cardiovascular disease (CVD) and cause few adverse effects. Half of patients prescribed statins discontinue treatment due to perceived intolerance. Placebo-controlled (blinded) n-of-1 trials have shown people with perceived intolerance that the statin does not cause adverse events and most resume treatment. However, blinded n-of-1 trials are impractical to deliver in routine practice. Tackling Statin Intolerance using n-of-1 tr...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1136/bmjopen-2019-033070

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Primary Care Health Sciences
Sub department:
Primary Care Health Sciences
Role:
Author
ORCID:
0000-0001-8244-9650
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Primary Care Health Sciences
Sub department:
Primary Care Health Sciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
HUMS
Department:
Philosophy Faculty
Role:
Author
ORCID:
0000-0003-0280-7206
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Primary Care Health Sciences
Sub department:
Primary Care Health Sciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Primary Care Health Sciences
Sub department:
Primary Care Health Sciences
Role:
Author
ORCID:
0000-0002-1802-4217
Publisher:
BMJ Publisher's website
Journal:
BMJ Open Journal website
Volume:
10
Issue:
2
Pages:
e033070
Place of publication:
England
Publication date:
2020-02-12
Acceptance date:
2019-12-20
DOI:
EISSN:
2044-6055
ISSN:
2044-6055
Pmid:
32051312
Language:
English
Keywords:
Pubs id:
1087304
Local pid:
pubs:1087304
Deposit date:
2020-03-20

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