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Stromal uptake and transmission of acid is a pathway for venting cancer cell-generated acid

Abstract:

Proliferation and invasion of cancer cells require favorable pH, yet potentially toxic quantities of acid are produced metabolically. Membrane-bound transporters extrude acid from cancer cells, but little is known about the mechanisms that handle acid once it is released into the poorly-perfused extracellular space. Here, we studied acid-handling by stromal myofibroblasts (colon cancer-derived Hs675.T, intestinal InMyoFib, embryonic colon-derived CCD-112-CoN), skin fibroblasts (NHDF-Ad) and c...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1073/pnas.1610954113

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
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Institution:
University of Oxford
Division:
UAS
Department:
Academic Administration Division
Sub department:
Divisional Administration
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
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Institution:
University of Oxford
Oxford college:
Hertford College
Role:
Author
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Funding agency for:
Bodmer, W
Grant:
278204
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Funding agency for:
Bodmer, W
Grant:
278204
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Funding agency for:
Swietach, P
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Publisher:
National Academy of Sciences Publisher's website
Journal:
Proceedings of the National Academy of Sciences of USA Journal website
Publication date:
2016-08-01
Acceptance date:
2016-07-19
DOI:
ISSN:
1091-6490
Source identifiers:
635169
Keywords:
Pubs id:
pubs:635169
UUID:
uuid:85a3008c-2158-4c60-b2ab-191414c5471c
Local pid:
pubs:635169
Deposit date:
2016-08-03

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