MAIT cells are activated during human viral infections.
Mucosal-associated invariant T (MAIT) cells are abundant in humans and recognize bacterial ligands. Here, we demonstrate that MAIT cells are also activated during human viral infections in vivo. MAIT cells activation was observed during infection with dengue virus, hepatitis C virus and influenza virus. This activation—driving cytokine release and Granzyme B upregulation—is TCR-independent but dependent on IL-18 in synergy with IL-12, IL-15 and/or interferon-α/β. IL-18 levels and MAIT cell ac...Expand abstract
- Publication status:
- Peer review status:
- Peer reviewed
(Version of record, pdf, 891.1KB)
- Publisher copy:
- Copyright holder:
- van Wilgenburg et al
- Copyright date:
- Author(s) retain copyright; published by Nature Publishing Group under a Creative Commons Attribution 4.0 International License.
- CC Attribution (CC BY)
If you are the owner of this record, you can report an update to it here: Report update to this record