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Journal article

MAIT cells are activated during human viral infections.

Abstract:

Mucosal-associated invariant T (MAIT) cells are abundant in humans and recognize bacterial ligands. Here, we demonstrate that MAIT cells are also activated during human viral infections in vivo. MAIT cells activation was observed during infection with dengue virus, hepatitis C virus and influenza virus. This activation—driving cytokine release and Granzyme B upregulation—is TCR-independent but dependent on IL-18 in synergy with IL-12, IL-15 and/or interferon-α/β. IL-18 levels and MAIT cell ac...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/ncomms11653

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Institution:
University of Oxford
Division:
MSD
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Role:
Author
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Grant:
PS2186_WMII
WT091663MA
More from this funder
Grant:
STOP-HCV consortium
MR/K000241/1
Project Grant G0600371
Oxford Martin School More from this funder
Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Communications Journal website
Publication date:
2016-06-23
Acceptance date:
2016-04-07
DOI:
EISSN:
2041-1723
ISSN:
2041-1723
Pmid:
27337592
Source identifiers:
617901
Language:
English
Keywords:
Pubs id:
pubs:617901
UUID:
uuid:867621ce-faa7-4a91-b9eb-d0f1ccefc81b
Local pid:
pubs:617901
Deposit date:
2016-09-09

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