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Dataset

Human DNA Cross-Link Repair 1A (DCLRE1A, SNM1A); A Target Enabling Package

Version:
3

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Genomics Consortium
Role:
Principal Investigator (PI), Creator

Contributors

Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Genomics Consortium
Role:
Researcher
Institution:
University of Oxford
Oxford college:
Balliol College
Role:
Researcher
Role:
Researcher
Department:
Oncology
Role:
Researcher
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Researcher
Publisher:
University of Oxford
Publication date:
2018
Version number:
3
Keywords:
Subjects:
Documentation:
A description of the materials and methods is included within the TEP datasheet. Cancer cells experience genomic instability, probably through a combination of excessive replicative activity and the loss of function of checkpoint and DNA repair pathways that may have contributed to the oncogenic transformation. Chemotherapy by DNA-damaging agents such as cisplatin and nitrogen mustards create DNA interstrand crosslinks (ICL), which can lead to double-strand breaks and cell death when the cell... Expand documentation
UUID:
uuid:86c6ec36-8e5e-43b2-9dc0-36e0a35d1b11
Deposit date:
2018-05-08

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