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Genome-wide mapping of susceptibility to coronary artery disease identifies a novel replicated locus on Chromosome 17

Abstract:

Coronary artery disease (CAD) is a leading cause of death world-wide, and most cases have a complex, multifactorial aetiology that includes a substantial heritable component. Identification of new genes involved in CAD may inform pathogenesis and provide new therapeutic targets.The PROCARDIS study recruited 2,658 affected sibling pairs (ASPs) with onset of CAD before age 66 y from four European countries to map susceptibility loci for CAD. ASPs were defined as having CAD phenotype if both had...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pgen.0020072

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Institution:
University of Oxford
Department:
Medical Sciences Division - Cardiovascular Medicine
Role:
Author
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Institution:
University of Surrey
Department:
School of Biomedical and Molecular Sciences
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Author
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Institution:
University of Oxford
Department:
Medical Sciences Division - Cardiovascular Medicine
Role:
Author
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Institution:
"AstraZeneca AB, Mölndal, Sweden"
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Author
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Institution:
University of Oxford
Department:
Clinical Trials Service Unit and Epidemiological Studies Unit
Role:
Author
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Journal:
PLoS Genetics Journal website
Volume:
2
Issue:
5
Pages:
e72
DOI:
EISSN:
1553-7404
ISSN:
1553-7390
Language:
English
Keywords:
Subjects:
UUID:
uuid:87c2230f-2bc5-410b-a1b4-a4542a38e070
Local pid:
ora:967
Deposit date:
2008-03-14

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