Journal article icon

Journal article

Importance of lateral and steric stabilization of polyelectrolyte gene delivery vectors for extended systemic circulation

Abstract:

Gene therapy for systemic diseases requires intravenous administration, but existing vectors are not suitable for systemic delivery, often showing rapid elimination from the bloodstream that restricts potential transfection sites to “first-pass” organs. To develop long-circulating vectors, here we have compared polyplexes containing DNA and poly-L-lysine (PLL) or polyethylenimine (PEI), surface-modified with either monovalent polyethylene glycol (PEG) or multivalent copolymers of N-(2-hydroxy...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1006/mthe.2002.0568

Authors


Expand authors...
Publisher:
Cell Press Publisher's website
Journal:
Molecular Therapy Journal website
Volume:
5
Issue:
4
Pages:
463-472
Publication date:
2002-04-01
DOI:
EISSN:
1525-0024
ISSN:
1525-0016
Source identifiers:
709381
Keywords:
Pubs id:
pubs:709381
UUID:
uuid:87c9798e-8457-4436-bb65-8d3e2e8a2fe1
Local pid:
pubs:709381
Deposit date:
2017-07-27

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP