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Thesis

The role of genetic variation in glucokinase and glucokinase regulatory protein in diabetes and related traits

Abstract:

The rising prevalence of type 2 diabetes (T2D) is a global problem, and suggests that we need better therapeutic strategies against this disease. The glycolytic enzyme glucokinase (GCK) catalyses the phosphorylation of glucose, and is a well-established T2D drug target. Rare GCK mutations cause monogenic beta-cell dysfunction, whilst common genetic variants within GCK are associated with fasting plasma glucose (FPG) levels and T2D risk. Since GCK is expressed in both the pancreas and liver...

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Research group:
Gloyn-McCarthy
Oxford college:
Green Templeton College
Role:
Author
More by this author
Division:
MSD
Department:
NDM
Role:
Author

Contributors

Division:
MSD
Department:
NDM
Role:
Supervisor
Division:
MSD
Department:
NDM
Role:
Supervisor
Publication date:
2011
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:87f8ea0d-9528-49fd-8f01-5f976cf9f210
Local pid:
ora:5640
Deposit date:
2011-08-15

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