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Thesis

Biochemical and functional studies of the histone demethylases

Abstract:

Histone lysine methylation is an important post-translational modification (PTM), directing the regulation of gene expression in eukaryotic genomes. Methylation states are dynamically altered by the activity of methyl-transferases and demethylases, including the JmjC 2OG oxygenase Lysine Demethylases (KDMs). KDMs have been associated with perturbed chromatin methylation profiles seen in several pathologies, including cancer and developmental disorders. There is much interest in elucidating...

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Division:
MPLS
Department:
Chemistry
Sub department:
Chemical Biology
Department:
University of Oxford
Role:
Author

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Supervisor
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Supervisor
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Examiner
Department:
Medical Research Council
Role:
Examiner
Type of award:
MSc by Research
Level of award:
Masters
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:881abd01-99be-4686-9873-ea0461ebe978
Deposit date:
2016-09-21

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