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Thesis

Site-specific chemical modification of antibodies for the modulation of function

Abstract:

Chemical modification of antibodies is critical for many research areas including therapeutic and biotechnological applications. In particular, strategies for site-specific chemical modification via non-natural amino acids forming homogenous immunoconjugates are of interest. The use of fully functional single-domain antibodies derived from naturally occurring heavy chain antibodies in Camelidae species is attractive due to their enhanced properties, which are discussed in this pie...

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Chemistry Research Laboratory
Research group:
Professor Ben Davis
Oxford college:
St Cross College
Role:
Author

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Role:
Supervisor
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Funding agency for:
Gunnoo, S
Grant:
DMRRBJ0
Publication date:
2013
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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