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Journal article

Liver macrophages inhibit the endogenous antioxidant response in obesity-associated insulin resistance

Abstract:

Obesity and insulin resistance are risk factors for nonalcoholic fatty liver disease (NAFLD), the most common chronic liver disease worldwide. Because no approved medication nor an accurate and noninvasive diagnosis is currently available for NAFLD, there is a clear need to better understand the link between obesity and NAFLD. Lipid accumulation during obesity is known to be associated with oxidative stress and inflammatory activation of liver macrophages (LMs). However, we show that although...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1126/scitranslmed.aaw9709

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Role:
Author
ORCID:
0000-0003-4141-961X
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Role:
Author
ORCID:
0000-0003-3740-9742
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Role:
Author
ORCID:
0000-0002-8068-1891
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Role:
Author
ORCID:
0000-0003-3142-2508
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Publisher:
American Association for the Advancement of Science Publisher's website
Journal:
Science Translational Medicine Journal website
Volume:
12
Issue:
532
Article number:
eaaw9709
Publication date:
2020-02-26
Acceptance date:
2020-02-06
DOI:
EISSN:
1946-6242
ISSN:
1946-6234
Pmid:
32102936
Language:
English
Keywords:
Pubs id:
1090257
Local pid:
pubs:1090257
Deposit date:
2020-07-21

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