Journal article
Liver macrophages inhibit the endogenous antioxidant response in obesity-associated insulin resistance
- Abstract:
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Obesity and insulin resistance are risk factors for nonalcoholic fatty liver disease (NAFLD), the most common chronic liver disease worldwide. Because no approved medication nor an accurate and noninvasive diagnosis is currently available for NAFLD, there is a clear need to better understand the link between obesity and NAFLD. Lipid accumulation during obesity is known to be associated with oxidative stress and inflammatory activation of liver macrophages (LMs). However, we show that although...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Accepted manuscript, 6.4MB)
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- Publisher copy:
- 10.1126/scitranslmed.aaw9709
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Authors
Bibliographic Details
- Publisher:
- American Association for the Advancement of Science Publisher's website
- Journal:
- Science Translational Medicine Journal website
- Volume:
- 12
- Issue:
- 532
- Article number:
- eaaw9709
- Publication date:
- 2020-02-26
- Acceptance date:
- 2020-02-06
- DOI:
- EISSN:
-
1946-6242
- ISSN:
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1946-6234
- Pmid:
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32102936
Item Description
- Language:
- English
- Keywords:
- Pubs id:
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1090257
- Local pid:
- pubs:1090257
- Deposit date:
- 2020-07-21
Terms of use
- Copyright holder:
- Azzimato et al.
- Copyright date:
- 2020
- Rights statement:
- Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
- Notes:
- This is the accepted manuscript version of the article. The final version is available online from AAAS at https://doi.org/10.1126/scitranslmed.aaw9709
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