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The role of histone modification in DNA double-strand break repair in Schizosaccharomyces pombe

Abstract:

DNA double-strand breaks (DSBs) are highly genotoxic lesions, which when incorrectly repaired can lead to gross chromosomal rearrangements and tumourigenesis through oncogene activation or loss of heterozygosity at tumour suppressor loci. Chromatin structure and therefore histone modification can play a key role in the repair of these lesions through affecting the access of repair machinery to the break. To identify novel histone-modifying enzymes involved in DSB repair, nineteen histone-m...

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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Sub department:
CRUK/MRC Ox Inst for Radiation Oncology
Research group:
Chromosome Integrity Group
Oxford college:
Christ Church
Role:
Author

Contributors

Role:
Supervisor
Publication date:
2012
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
Language:
English
Keywords:
Subjects:
UUID:
uuid:88998b84-da94-40dc-80d0-ef46c51d20d1
Local pid:
ora:6785
Deposit date:
2013-03-27

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