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Journal article

Striking parallels between carotid body glomus cell and adrenal chromaffin cell development

Abstract:

Carotid body glomus cells mediate essential reflex responses to arterial blood hypoxia. They are dopaminergic and secrete growth factors that support dopaminergic neurons, making the carotid body a potential source of patient-specific cells for Parkinson's disease therapy. Like adrenal chromaffin cells, which are also hypoxia-sensitive, glomus cells are neural crest-derived and require the transcription factors Ascl1 and Phox2b; otherwise, their development is little understood at the molecul...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.ydbio.2018.05.016

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Role:
Author
ORCID:
0000-0003-2613-6216
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Role:
Author
ORCID:
0000-0002-8781-9769
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Publisher:
Elsevier Publisher's website
Journal:
Developmental Biology Journal website
Volume:
444
Issue:
S1
Pages:
S308-S324
Publication date:
2018-05-25
Acceptance date:
2018-05-20
DOI:
EISSN:
1095-564X
ISSN:
0012-1606
Pmid:
29807017
Source identifiers:
895677
Language:
English
Keywords:
Pubs id:
pubs:895677
UUID:
uuid:89bc7fa7-5580-4683-8ef7-7f8d3e7887f6
Local pid:
pubs:895677
Deposit date:
2019-07-08

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