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Journal article

Early onset of ataxia in moonwalker mice is accompanied by complete ablation of type II unipolar brush cells and Purkinje cell dysfunction.

Abstract:

Transient receptor potential "canonical" cation channels (TRPC) are involved in many cellular activities, including neuronal synaptic transmission. These channels couple lipid metabolism, calcium homeostasis, and electrophysiological properties as they are calcium permeable and activated through the phospholipase C pathway and by diacylglycerol. The TRPC3 subunit is abundantly expressed in Purkinje cells (PCs), where it mediates slow metabotropic glutamate receptor-mediated synaptic responses...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1523/jneurosci.2294-13.2013

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
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Funding agency for:
Becker, E
Journal:
Journal of neuroscience : the official journal of the Society for Neuroscience
Volume:
33
Issue:
50
Pages:
19689-19694
Publication date:
2013-12-01
DOI:
EISSN:
1529-2401
ISSN:
0270-6474
Source identifiers:
443411
Language:
English
Keywords:
Pubs id:
pubs:443411
UUID:
uuid:89e46eb4-eae7-4ace-8417-0feef2f97a00
Local pid:
pubs:443411
Deposit date:
2014-01-30

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