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Thesis

The development and application of novel magnetic resonance spectroscopic and imaging techniques to assess cardiac energetics and substrate handling in the human heart

Abstract:

Myocardial energy homeostasis requires an interplay between three stages of energy transduction; the choice of substrate oxidised, the rate of mitochondrial oxidative phosphorylation, and finally transfer of adenosine triphosphate (ATP) to sites of disposal via the intermediate phosphocreatine (PCr). Whilst all three elements are fundamental, until recently, non-invasive assessment was limited to 31Phosphorus magnetic resonance spectroscopy (31P-MRS) assessment of the...

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MSD
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Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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