Journal article
Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits
- Abstract:
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High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identi...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Accepted manuscript, pdf, 514.2KB)
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- Publisher copy:
- 10.1038/s41588-018-0205-x
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Authors
Funding
+ National Institutes of Health
More from this funder
Funding agency for:
Lindgren, CM
Grant:
CRR00070 CR00.01
+ BHF Centre of Research Excellence
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Funding agency for:
Farrall, M
Grant:
RE/13/1/30181
+ European Union
More from this funder
Funding agency for:
Goel, A
Grant:
FP7/2007-2013 under grant agreement no. HEALTH-F2-2013-601456 (CVGenes@Target)
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Bibliographic Details
- Publisher:
- Springer Nature Publisher's website
- Journal:
- Nature Genetics Journal website
- Volume:
- 50
- Issue:
- 10
- Pages:
- 1412-1425
- Publication date:
- 2018-09-17
- Acceptance date:
- 2018-07-09
- DOI:
- EISSN:
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1546-1718
- ISSN:
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1061-4036
- Pmid:
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30224653
- Source identifiers:
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920322
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:920322
- UUID:
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uuid:8a5a8b19-a731-4776-89d3-0ec188ff95cd
- Local pid:
- pubs:920322
- Deposit date:
- 2018-11-19
Terms of use
- Copyright holder:
- Evangelou et al
- Copyright date:
- 2018
- Notes:
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This is the accepted manuscript version of the article. The final version is available online from Springer Nature at: https://doi.org/10.1038/s41588-018-0205-x
A correction to this article is available at: https://doi.org/10.1038/s41588-018-0297-3
If you are the owner of this record, you can report an update to it here: Report update to this record