Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

Evangelou, E; Warren, HR; Mosen-Ansorena, D; Mifsud, B; Pazoki, R; Gao, H; Ntritsos, G; Dimou, N; Cabrera, CP; Karaman, I; Ng, FL; Evangelou, M; Witkowska, K; Tzanis, E; Hellwege, JN; Giri, A; Edwards, DR; Sun, YV; Cho, K; Gaziano, JM; Wilson, PWF; Tsao, PS; Kovesdy, CP; Esko, T; Mägi, R; Milani, L; Almgren, P; Boutin, T; Debette, S; Ding, J; Giulianini, F; Holliday, EG; Jackson, AU; Li-Gao, R; Lin, W-Y; Luan, J; Mangino, M; Oldmeadow, C; Prins, BP; Qian, Y; Sargurupremraj, M; Shah, N; Surendran, P; Thériault, S; Verweij, N; Willems, SM; Zhao, J-H; Amouyel, P; Connell, J; De Mutsert, R; Doney, ASF; Farrall, M; Menni, C; Morris, AD; Noordam, R; Paré, G; Poulter, NR; Shields, DC; Stanton, A; Thom, S; Abecasis, G; Amin, N; Arking, DE; Ayers, KL; Barbieri, CM; Batini, C; Bis, JC; Blake, T; Bochud, M; Boehnke, M; Boerwinkle, E; Boomsma, DI; Bottinger, EP; Braund, PS; Brumat, M; Campbell, A; Campbell, H; Chakravarti, A; Chambers, JC; Chauhan, G; Ciullo, M; Cocca, M; Collins, F; Cordell, HJ; Davies, G; Borst, MHD; Geus, EJD; Deary, IJ; Deelen, J; Del Greco M, F; Demirkale, CY; Dörr, M; Ehret, GB; Elosua, R; Enroth, S; Erzurumluoglu, AM; Ferreira, T; Frånberg, M; Franco, OH; Gandin, I; Gasparini, P; Giedraitis, V; Gieger, C; Girotto, G; Goel, A; Gow, AJ; Gudnason, V; Guo, X; Gyllensten, U; Hamsten, A; Harris, TB; Harris, SE; Hartman, CA; Havulinna, AS; Hicks, AA; Hofer, E; Hofman, A; Hottenga, J-J; Huffman, JE; Hwang, S-J; Ingelsson, E; James, A; Jansen, R; Jarvelin, M-R; Joehanes, R; Johansson, Å; Johnson, AD; Joshi, PK; Jousilahti, P; Jukema, JW; Jula, A; Kähönen, M; Kathiresan, S; Keavney, BD; Khaw, K-T; Knekt, P; Knight, J; Kolcic, I; Kooner, JS; Koskinen, S; Kristiansson, K; Kutalik, Z; Laan, M; Larson, M; Launer, LJ; Lehne, B; Lehtimäki, T; Liewald, DCM; Lin, L; Lind, L; Lindgren, CM; Liu, Y; Loos, RJF; Lopez, LM; Lu, Y; Lyytikäinen, L-P; Mahajan, A; Mamasoula, C; Marrugat, J; Marten, J; Milaneschi, Y; Morgan, A; Morris, AP; Morrison, AC; Munson, PJ; Nalls, MA; Nandakumar, P; Nelson, CP; Niiranen, T; Nolte, IM; Nutile, T; Oldehinkel, AJ; Oostra, BA; O'Reilly, PF; Org, E; Padmanabhan, S; Palmas, W; Palotie, A; Pattie, A; Penninx, BWJH; Perola, M; Peters, A; Polasek, O; Pramstaller, PP; Nguyen, QT; Raitakari, OT; Ren, M; Rettig, R; Rice, K; Ridker, PM; Ried, JS; Riese, H; Ripatti, S; Robino, A; Rose, LM; Rotter, JI; Rudan, I; Ruggiero, D; Saba, Y; Sala, CF; Salomaa, V; Samani, NJ; Sarin, A-P; Schmidt, R; Schmidt, H; Shrine, N; Siscovick, D; Smith, AV; Snieder, H; Sõber, S; Sorice, R; Starr, JM; Stott, DJ; Strachan, DP; Strawbridge, RJ; Sundström, J; Swertz, MA; Taylor, KD; Teumer, A; Tobin, MD; Tomaszewski, M; Toniolo, D; Traglia, M; Trompet, S; Tuomilehto, J; Tzourio, C; Uitterlinden, AG; Vaez, A; Van Der Most, PJ; Van Duijn, CM; Vergnaud, A-C; Verwoert, GC; Vitart, V; Völker, U; Vollenweider, P; Vuckovic, D; Watkins, H; Wild, SH; Willemsen, G; Wilson, JF; Wright, AF; Yao, J; Zemunik, T; Zhang, W; Attia, JR; Butterworth, AS; Chasman, DI; Conen, D; Cucca, F; Danesh, J; Hayward, C; Howson, JMM; Laakso, M; Lakatta, EG; Langenberg, C; Melander, O; Mook-Kanamori, DO; Palmer, CNA; Risch, L; Scott, RA; Scott, RJ; Sever, P; Spector, TD; Van Der Harst, P; Wareham, NJ; Zeggini, E; Levy, D; Munroe, PB; Newton-Cheh, C; Brown, MJ; Metspalu, A; Hung, AM; O'Donnell, CJ; Edwards, TL; Million Veteran Program; Psaty, BM; Tzoulaki, I; Barnes, MR; Wain, LV; Elliott, P; Caulfield, MJ

Journal article

Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

Abstract:: High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identi...
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Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Evangelou, E., Warren, H. R., Mosen-Ansorena, D., Mifsud, B., Pazoki, R., Gao, H., Ntritsos, G., Dimou, N., Cabrera, C. P., Karaman, I., Ng, F. L., Evangelou, M., Witkowska, K., Tzanis, E., Hellwege, J. N., Giri, A., Edwards, D. R., Sun, Y. V., Cho, K., … Caulfield, M. J. (2018). Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. Nature Genetics, 50(10), 1412–1425.

MLA Style

Evangelou, E., et al. “Genetic Analysis of over 1 Million People Identifies 535 New Loci Associated with Blood Pressure Traits.” Nature Genetics, vol. 50, no. 10, Springer Nature, 2018, pp. 1412–25.

Chicago Style

Evangelou, E, HR Warren, D Mosen-Ansorena, B Mifsud, R Pazoki, H Gao, G Ntritsos, et al. 2018. “Genetic Analysis of over 1 Million People Identifies 535 New Loci Associated with Blood Pressure Traits.” Nature Genetics 50 (10): 1412–25.
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Files:: NG_Manuscript_Final.pdf

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Publisher copy:: 10.1038/s41588-018-0205-x

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+ Evangelou, E More by this author

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0000-0002-5488-2999

+ Warren, HR More by this author

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+ Mosen-Ansorena, D More by this author

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+ Mifsud, B More by this author

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+ Pazoki, R More by this author

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+ Widenlife More from this funder

Funding agency for:

Lindgren, CM

Grant:

CRR00070 CR00.01

+ John Fell Fund More from this funder

Funding agency for:

Lindgren, CM

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CRR00070 CR00.01

+ Li Ka Shing Foundation More from this funder

Funding agency for:

Lindgren, CM

Grant:

CRR00070 CR00.01

+ European Union More from this funder

Funding agency for:

Goel, A

Watkins, H

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FP7/2007-2013 under grant agreement no. HEALTH-F2-2013-601456 (CVGenes@Target)

+ NIHR Oxford Biomedical Research Centre More from this funder

Funding agency for:

Ferreira, T

Lindgren, CM

Grant:

CRR00070 CR00.01

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Bibliographic Details

Publisher:: Springer Nature Publisher's website
Journal:: Nature Genetics Journal website
Volume:: 50
Issue:: 10
Pages:: 1412-1425
Publication date:: 2018-09-17
Acceptance date:: 2018-07-09
DOI:: 10.1038/s41588-018-0205-x
EISSN:: 1546-1718
ISSN:: 1061-4036
Pmid:: 30224653

Item Description

Language:: English
Keywords:: Million Veteran Program
Pubs id:: pubs:920322
UUID:: uuid:8a5a8b19-a731-4776-89d3-0ec188ff95cd
Local pid:: pubs:920322
Source identifiers:: 920322
Deposit date:: 2018-11-19

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Copyright holder:: Evangelou et al
Notes:: This is the accepted manuscript version of the article. The final version is available online from Springer Nature at: https://doi.org/10.1038/s41588-018-0205-x

A correction to this article is available at: https://doi.org/10.1038/s41588-018-0297-3

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Journal article

Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

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