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Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

Abstract:

High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identi...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41588-018-0205-x

Authors


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Role:
Author
ORCID:
0000-0002-5488-2999
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Funding agency for:
Lindgren, CM
Grant:
CRR00070 CR00.01
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Funding agency for:
Farrall, M
Grant:
RE/13/1/30181
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Funding agency for:
Farrall, M
Grant:
RE/13/1/30181
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Funding agency for:
Goel, A
Grant:
FP7/2007-2013 under grant agreement no. HEALTH-F2-2013-601456 (CVGenes@Target)
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Publisher:
Springer Nature Publisher's website
Journal:
Nature Genetics Journal website
Volume:
50
Issue:
10
Pages:
1412-1425
Publication date:
2018-09-17
Acceptance date:
2018-07-09
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
Pmid:
30224653
Source identifiers:
920322
Language:
English
Keywords:
Pubs id:
pubs:920322
UUID:
uuid:8a5a8b19-a731-4776-89d3-0ec188ff95cd
Local pid:
pubs:920322
Deposit date:
2018-11-19

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