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Molecular profiling CD8+ T-cell memory inflation

Abstract:

Infection with murine cytomegalovirus (MCMV) induces a large population of virus-specific CD8+ T-cells that is maintained at a high frequency in the peripheral organs for the lifetime of the host. This striking response to MCMV is termed "memory inflation". It has also been shown that a similar response occurs after immunization with a non-replicating adenovirus expressing a transgene. The key features which distinguish "inflating" CD8+ T-cell memory responses from classical "non-inflating...

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Oxford college:
Brasenose College
Role:
Author

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Role:
Supervisor
Publication date:
2013
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:8a617313-aeb0-4bba-b8e7-89ca25715a1c
Deposit date:
2016-11-15

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