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Predictive value of telomere length on outcome following acute myocardial infarction: Evidence for contrasting effects of vascular vs. blood oxidative stress

Abstract:
Aims: Experimental evidence suggests that telomere length (TL) is shortened by oxidative DNA damage, reflecting biological aging. We explore the value of blood (BTL) and vascular (VTL) TL as biomarkers of systemic/vascular oxidative stress in humans and test the clinical predictive value of BTL in acute myocardial infarction (AMI). Methods and Results: In a prospective cohort of 290 patients surviving recent AMI, BTL measured on admission was a strong predict... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/eurheartj/ehx177

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Oxford college:
Trinity College
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
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Funding agency for:
Margaritis, M
Grant:
RE/08/004
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Funding agency for:
Sanna, F
Grant:
ITN network RADOX
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Funding agency for:
Channon, K
Grant:
ITN network RADOX
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Funding agency for:
Antoniades, C
Grant:
ITN network RADOX
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Publisher:
Oxford University Press Publisher's website
Journal:
European Heart Journal Journal website
Volume:
38
Issue:
41
Pages:
3094–3104
Publication date:
2017-04-24
Acceptance date:
2017-03-14
DOI:
EISSN:
1522-9645
ISSN:
0195-668X
Source identifiers:
685955
Keywords:
Pubs id:
pubs:685955
UUID:
uuid:8a72f885-6518-4787-9a9f-b1b37696e9e3
Local pid:
pubs:685955
Deposit date:
2017-03-15

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