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Journal article

Opposing effects of HLA class I molecules in tuning autoreactive CD8+ T cells in multiple sclerosis.

Abstract:

The major known genetic risk factors in multiple sclerosis reside in the major histocompatibility complex (MHC) region. Although there is strong evidence implicating MHC class II alleles and CD4(+) T cells in multiple sclerosis pathogenesis, possible contributions from MHC class I genes and CD8(+) T cells are controversial. We have generated humanized mice expressing the multiple sclerosis-associated MHC class I alleles HLA-A(*)0301 (encoding human leukocyte antigen-A3 (HLA-A3)) and HLA-A(*)0...

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Publication status:
Published

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Publisher copy:
10.1038/nm.1881

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Journal:
Nature medicine
Volume:
14
Issue:
11
Pages:
1227-1235
Publication date:
2008-11-01
DOI:
EISSN:
1546-170X
ISSN:
1078-8956
Source identifiers:
18385
Language:
English
Keywords:
Pubs id:
pubs:18385
UUID:
uuid:8ac9c0ce-8185-4dab-97fb-8041b0c16c4d
Local pid:
pubs:18385
Deposit date:
2012-12-19

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