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Journal article

Defining murine organogenesis at single-cell resolution reveals a role for the leukotriene pathway in regulating blood progenitor formation.

Abstract:

During gastrulation, cell types from all three germ layers are specified and the basic body plan is established 1 . However, molecular analysis of this key developmental stage has been hampered by limited cell numbers and a paucity of markers. Single-cell RNA sequencing circumvents these problems, but has so far been limited to specific organ systems 2 . Here, we report single-cell transcriptomic characterization of >20,000 cells immediately following gastrulation at E8.25 of mouse develop...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41556-017-0013-z

Authors


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Role:
Author
ORCID:
0000-0002-4956-2843
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Medical Research Council More from this funder
Cancer Research UK More from this funder
Leukemia and Lymphoma Society More from this funder
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Cell Biology Journal website
Volume:
20
Issue:
2
Pages:
127-134
Publication date:
2018-01-01
Acceptance date:
2017-11-21
DOI:
EISSN:
1476-4679
ISSN:
1465-7392
Pmid:
29311656
Source identifiers:
817644
Language:
English
Keywords:
Pubs id:
pubs:817644
UUID:
uuid:8b151215-0f2c-4dec-83c3-44087710661a
Local pid:
pubs:817644
Deposit date:
2018-02-27

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