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Very low calorie diets are associated with transient ventricular impairment before reversal of diastolic dysfunction in obesity

Abstract:
Objectives Very low calorie diets (VLCDs) are effective at clearing hepatic steatosis and improving insulin sensitivity. Whilst long-term weight loss is beneficial to the cardiovascular system, the acute elevation in fatty acids during caloric restriction is potentially detrimental to cardiac metabolism and function. We sought to investigate any cardiovascular changes occurring over the course of a modern VLCD regime, alongside the expected peripheral metabolic improvements. ... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41366-018-0263-2

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
ORCID:
0000-0002-3519-5480
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Oxford college:
St Catherine's College
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Sub department:
Surgical Sciences
Oxford college:
Trinity College
Role:
Author
ORCID:
0000-0002-4674-0210
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
Publisher:
Springer Nature Publisher's website
Journal:
International journal of obesity Journal website
Volume:
43
Pages:
2536–2544
Publication date:
2018-11-21
Acceptance date:
2018-10-26
DOI:
EISSN:
1476-5497
ISSN:
0307-0565
Pmid:
30464235
Source identifiers:
946776
Language:
English
Pubs id:
pubs:946776
UUID:
uuid:8bd74796-3ff6-4cdc-94d5-9800bc09b6ea
Local pid:
pubs:946776
Deposit date:
2019-01-07

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