Thesis
How the protein antibiotic pyocin S5 kills Pseudomonas aeruginosa
- Abstract:
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Antimicrobial resistance is a deadly threat that is on the rise globally. Failure of small molecule antibiotic drug discovery programs and an increasing understanding of the dangers of antibiotic-induced dysbiosis of the microbiome have led to interest in bacteriocins as narrow-spectrum antibiotics. Pyocin S5 (PyoS5), a protein antibiotic against Pseudomonas aeruginosa, is the most potent colicin-like bacteriocin known but its structure and molecular mechanism remain poorly unders...
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Funding
Bibliographic Details
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:8c00e14e-1703-4a36-b4ae-d685bf04dda1
- Deposit date:
- 2019-12-17
Terms of use
- Copyright holder:
- Behrens, H
- Copyright date:
- 2019
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