Selective permeabilisation of the blood-brain barrier at sites of metastasis.
Over one in five cancer patients will develop brain metastases and prognosis remains poor. Effective chemotherapeutics for primary systemic tumours have limited access to brain metastases owing to the blood-brain barrier (BBB). The aim of this study was to develop a strategy for specifically permeabilising the BBB at sites of cerebral metastases.
Tumour necrosis factor was injected intravenously into mouse models of haematogenously induced brain metastasis. BBB permeability was ass...Expand abstract
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- Oxford University, UK
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- John Connell
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