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Biochemical mechanisms of vertebrate hedgehog signaling

Abstract:

Signaling pathways that mediate cell-cell communication are essential for collective cell behaviors in multicellular systems. The hedgehog (HH) pathway, first discovered and elucidated in Drosophila, is one of these iconic signaling systems that plays many roles during embryogenesis and in adults; abnormal HH signaling can lead to birth defects and cancer. We review recent structural and biochemical studies that have advanced our understanding of the vertebrate HH pathway, focusing on the mec...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1242/dev.166892

Authors


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Role:
Author
ORCID:
0000-0002-4573-3270
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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Biology
Oxford college:
St Cross College
Role:
Author
ORCID:
0000-0002-6635-3621
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Role:
Author
ORCID:
0000-0001-7609-8858
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Funding agency for:
Siebold, C
Grant:
647278
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Funding agency for:
Siebold, C
Grant:
647278
Publisher:
Company of Biologists Publisher's website
Journal:
Development Journal website
Volume:
146
Issue:
10
Article number:
dev166892
Publication date:
2019-05-15
DOI:
EISSN:
1477-9129
ISSN:
0950-1991
Pmid:
31092502
Source identifiers:
1003362
Language:
English
Keywords:
Pubs id:
pubs:1003362
UUID:
uuid:8c0a44f7-20b5-4751-8358-9573f1fb2c8d
Local pid:
pubs:1003362
Deposit date:
2019-07-26

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