Biochemical mechanisms of vertebrate hedgehog signaling
Signaling pathways that mediate cell-cell communication are essential for collective cell behaviors in multicellular systems. The hedgehog (HH) pathway, first discovered and elucidated in Drosophila, is one of these iconic signaling systems that plays many roles during embryogenesis and in adults; abnormal HH signaling can lead to birth defects and cancer. We review recent structural and biochemical studies that have advanced our understanding of the vertebrate HH pathway, focusing on the mec...Expand abstract
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- Peer reviewed
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- Kong et al.
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- © 2019 The Authors. Published by The Company of Biologists Ltd.
- This is the accepted manuscript version of the article. The final version is available online from the Company of Biologists at: https://doi.org/10.1242/dev.166892
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