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Journal article

Hidden heritability due to heterogeneity across seven populations.

Abstract:

Meta-analyses of genome-wide association studies (GWAS), which dominate genetic discovery are based on data from diverse historical time periods and populations. Genetic scores derived from GWAS explain only a fraction of the heritability estimates obtained from whole-genome studies on single populations, known as the 'hidden heritability' puzzle. Using seven sampling populations (N=35,062), we test whether hidden heritability is attributed to heterogeneity across sampling populations and tim...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41562-017-0195-1

Authors


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Institution:
University of Oxford
Division:
SSD
Department:
Sociology
Oxford college:
St Cross College
Role:
Author
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John Fell Fund More from this funder
Wellcome Trust More from this funder
Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Human Behaviour Journal website
Volume:
1
Issue:
10
Pages:
757-765
Publication date:
2017-09-01
Acceptance date:
2017-08-04
DOI:
EISSN:
2397-3374
ISSN:
2397-3374
Pmid:
29051922
Source identifiers:
738156
Language:
English
Keywords:
Pubs id:
pubs:738156
UUID:
uuid:8c6fa84e-ac6d-4baa-8cc7-675ef42fa841
Local pid:
pubs:738156
Deposit date:
2018-03-22

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