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First-trimester artemisinin derivatives and quinine treatments and the risk of adverse pregnancy outcomes in Africa and Asia: A meta-analysis of observational studies

Abstract:

BACKGROUND: Animal embryotoxicity data, and the scarcity of safety data in human pregnancies, have prevented artemisinin derivatives from being recommended for malaria treatment in the first trimester except in lifesaving circumstances. We conducted a meta-analysis of prospective observational studies comparing the risk of miscarriage, stillbirth, and major congenital anomaly (primary outcomes) among first-trimester pregnancies treated with artemisinin derivatives versus quinine or no antimal...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pmed.1002290

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
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Bill and Melinda Gates Foundation More from this funder
Wellcome Trust More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Medicine Journal website
Volume:
14
Issue:
5
Pages:
e1002290
Publication date:
2017-05-01
Acceptance date:
2017-03-23
DOI:
EISSN:
1549-1676
ISSN:
1549-1277
Source identifiers:
692357
Language:
English
Keywords:
Pubs id:
pubs:692357
UUID:
uuid:8cd0aca0-bfb2-4f91-9e7a-989340272734
Local pid:
pubs:692357
Deposit date:
2017-05-10

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