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Journal article

Tumor necrosis factor-alpha-converting enzyme (ADAM17) mediates the cleavage and shedding of fractalkine (CX3CL1).

Abstract:

Fractalkine (CX3CL1) is an unusual member of the chemokine family that is synthesized with its chemokine domain at the end of a mucin-rich, transmembrane stalk. This membrane-bound localization allows fractalkine to function as an adhesion molecule for cells bearing its receptor, CX3CR1. In addition, fractalkine can be proteolytically released from the cell surface, generating a soluble molecule that functions as a chemoattractant similar to the other members of the chemokine family. In this ...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.M106434200

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
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Journal:
Journal of biological chemistry
Volume:
276
Issue:
41
Pages:
37993-38001
Publication date:
2001-10-01
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
Source identifiers:
25673
Language:
English
Keywords:
Pubs id:
pubs:25673
UUID:
uuid:8cdc615d-b1ad-4d7a-80db-0ca23713be01
Local pid:
pubs:25673
Deposit date:
2012-12-19

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