Journal article
Tumor necrosis factor-alpha-converting enzyme (ADAM17) mediates the cleavage and shedding of fractalkine (CX3CL1).
- Abstract:
-
Fractalkine (CX3CL1) is an unusual member of the chemokine family that is synthesized with its chemokine domain at the end of a mucin-rich, transmembrane stalk. This membrane-bound localization allows fractalkine to function as an adhesion molecule for cells bearing its receptor, CX3CR1. In addition, fractalkine can be proteolytically released from the cell surface, generating a soluble molecule that functions as a chemoattractant similar to the other members of the chemokine family. In this ...
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- Publication status:
- Published
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- Publisher copy:
- 10.1074/jbc.M106434200
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Authors
Bibliographic Details
- Journal:
- Journal of biological chemistry
- Volume:
- 276
- Issue:
- 41
- Pages:
- 37993-38001
- Publication date:
- 2001-10-01
- DOI:
- EISSN:
-
1083-351X
- ISSN:
-
0021-9258
- Source identifiers:
-
25673
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:25673
- UUID:
-
uuid:8cdc615d-b1ad-4d7a-80db-0ca23713be01
- Local pid:
- pubs:25673
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2001
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