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With phases: how two wrongs can sometimes make a right

Abstract:

In isolation, both weak isomorphous/anomalous difference signals from heavy-atom derivatization and phases from partial molecular-replacement solutions for a subset of the asymmetric unit often fall short of producing interpretable electron-density maps. Phases generated from very partial molecular-replacement models (if generated carefully) can be used to reliably locate heavy-atom sites, even if the signal is not sufficiently strong to allow robust finding of the sites using Patterson inter...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1107/S0907444909048112

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
More from this funder
Funding agency for:
Roversi, P
Grant:
G0400775
More from this funder
Funding agency for:
Johnson, S
Grant:
WT083599MA
Publisher:
International Union of Crystallography Publisher's website
Journal:
Acta Crystallographica Section D: Biological Crystallography Journal website
Volume:
66
Issue:
4
Pages:
420-425
Publication date:
2010-04-01
DOI:
ISSN:
0907-4449
Language:
English
Subjects:
UUID:
uuid:8d7c730a-23c9-44fe-8427-b16155e6a832
Local pid:
ora:5589
Deposit date:
2011-07-20

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