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Journal article

FTO is expressed in neurones throughout the brain and its expression is unaltered by fasting.

Abstract:

Single-nucleotide polymorphisms in the first intron of the ubiquitously expressed FTO gene are associated with obesity. Although the physiological functions of FTO remain unclear, food intake is often altered when Fto expression levels are manipulated. Furthermore, deletion of FTO from neurones alone has a similar effect on food intake to deletion of FTO in all tissues. These results indicate that FTO expression in the brain is particularly important. Considerable focus has been placed on the...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pone.0027968

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Funding agency for:
Ashcroft, F
Medical Research Council More from this funder
Wellcome Trust More from this funder
Royal Society More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PloS one Journal website
Volume:
6
Issue:
11
Article number:
e27968
Publication date:
2011-01-01
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
Source identifiers:
216136
Language:
English
Keywords:
UUID:
uuid:8ea713f1-0a54-4717-b910-5c933a200737
Local pid:
pubs:216136
Deposit date:
2012-12-19

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